CNR1 and cyst: Thus, while the blockade of CB1 and CB2 receptors results at long term in i) a greater oedema expansion, ii) bigger cyst volume, iii) less white matter preservation, iv) worse myelin preservation and v) increased microgliosis, blocking CB2 receptors alone does not induce any of those histopathological alterations and CB1 blockade only produces a greater oedema expansion.