NOS2 and infection: Curiously, the curves for CD3, TNF-α, IFN-γ and iNOS transcripts of the two mouse strains intersected immediately after the fourth week of infection, a time point that is also marked by the appearance of motor impairments in IL-12p40KO mice, suggesting that the crescent inflammation thereafter presented by these mice is related to the development of the neurodegenerative process [11], which minimally results from the death of infected neurons.