Therefore, in this work, to study the NPC in HF patients, we performed a mapping of this complex through the study of different representative proteins that at different levels of this structure make up: transmembrane ring (NDC1), inner ring (Nup155), outer ring (Nup160), FG nucleoporins (Nup153), linker nucleoporins (Nup93) and the periphery nucleoporins of the nuclear face (TPR). Here, NPC1 is linked to hydrops fetalis.