To elucidate the contribution of RGD-binding integrins in the enhancing effect of Tat on MDDC infection, experiments were performed with either soluble cys22 Tat or coated wt Tat with MDDCs pre-incubated with a mixture of mAbs directed against the α5β1, αvβ3 and αvβ5 integrins. This evidence concerns the gene TAT and infection.