Moreover, 13q-H CLLs had higher levels of expression of LEF1, BCL2, CARD11, HDAC9, NAFTC1, NFATC2, PAX5, FCRL2 and SOS1, while we identified several other genes downregulated in 13q-H, such as GAS7, E2F1, RRM1, KIT, NP and EPOR. Many of these genes have been reported to be deregulated in CLL, as we confirmed in our analyses that showed overexpression of LEF1, NFATC1, NFATC2 and PAX5 in B lymphocytes from CLL patients compared with B lymphocytes from healthy controls (data not shown). The gene discussed is RRM1; the disease is B-cell chronic lymphocytic leukemia.