PRRT2 and B-cell chronic lymphocytic leukemia: Interestingly, CLL patients with deletions on 17p or 11q or those with losses in 13q in a high percentage of cells had an increased expression of a cluster of genes comprising several PKCs, such as PRKCB1 and PRKCZ. Previous studies have shown an overexpression of PKC in human CLLs, which is part of a poor-prognosis gene cluster in CLL linked to the transmission of BCR signals such as calcineurin-NFAT and NF-kB, which our analysis also revealed to be deregulated (Table 2) [31], [32].