Consistent with previous studies, lower CD4+ count [1], [2], [3], [7], [16], [18], [26] and higher VL [3], [15], [30] at baseline were predictors of paradoxical OI (mainly TB)-IRIS, but not unmasking IRIS, together with shorter period of pre-ART duration of OI/TB therapy OI-IRIS [13], [16], [28], [29], [30], [31], [51], which is likely to be related to a higher residual pathogen load. This evidence concerns the gene CD4 and tuberculosis.