Risk factors for Unmask-OI IRIS on multivariable analysis (Figure 4b) were evidence of lymphadenopathy vs. no lymphadenopathy on pre-ART chest x-ray (aHR 9.15, CI 4.10–20.42, P<0.001), haemoglobin <10 vs. >12 g/dL (aHR 3.36, CI 1.32–8.52, P = 0.011); CRP ≥25 vs. <25 mg/L (aHR 2.77, CI 1.31–5.85, P = 0.008), and ≥10% vs. <10% weight loss prior to ART (aHR 2.31, CI 1.05–5.11, P = 0.038). Here, CRP is linked to Lymphadenopathy.