CYP3A4 and Sepsis: Activities of rat CYP1A, CYP2A, CYP2B, CYP2C, and CYP2E (as assessed by the ethoxycoumarin O-deethylation model reaction) and CYP3A activity (as assessed by ethylmorphine N-demethylation) were significantly impaired in animals subjected to lethal sepsis compared to sham-treated animals (Figure 6A and 6B).