Absence of hyperbilirubinaemia and the inability of neutrophils to migrate into liver tissue in the septic PI3Kγ−/− mice were seen, notwithstanding higher levels of inflammatory cytokines (TNF-α and IL-6) and the chemoattractant MCP-1 (Figure 8D–8F). The gene discussed is TNF; the disease is Hyperbilirubinemia.