TCF7L2 and psychiatric disorder: For example, variants of the TCF7L2 gene have been associated with schizophrenia (Hansen et al. 2011; Alkelai et al. 2012), and anxiety-like phenotypes were observed in Tcf7l2 haplo-insufficient mice (Savic et al. 2011), suggesting the involvement of TCF7L2 in some psychiatric disorders.