AKT1 and non-small cell lung carcinoma: Examination of the PI3K/Akt/mTOR signaling pathway showed that OP-B selectively inhibits phosphorylation of Akt both at Ser473 and Thr308 in both of the two cell lines, suggesting that OP-B may be a potential inhibitor of the PI3K/Akt pathway for the treatment of NSCLC.