Moreover, recent data have indicated that the presence of CD4+ T cells at sites of motoneuron injury in mSOD1 mice shifts the balance of microglial response from decreased GNDF expression and increased TNF-α expression to increased GDNF expression and decreased TNF-α expression after inherited amyotrophic lateral sclerosis (ALS) (36). The gene discussed is CD4; the disease is amyotrophic lateral sclerosis.