Western blot analysis of MCF-7:5C tumor extracts showed that pSer167ERα, p-Akt, and p-RET protein were markedly reduced in the rPEDF-treated and rPEDF plus tamoxifen-treated samples compared with control or tamoxifen-treated samples (Figure 7d), which is consistent with our in vitro data. Here, AKT1 is linked to neoplasm.