As inflammation has emerged at the core pathophysiology of both diabetic nephropathy and atherosclerosis, we sought to investigate the relationships between serum MCP-1 concentrations with albuminuria, kidney function, and vascular calcification in a well-characterized cohort of AAs with type 2 diabetes (T2D) in the African American-Diabetes Heart Study (AA-DHS). Here, CCL2 is linked to type 2 diabetes mellitus.