A good example of this is colorectal adenocarcinoma, where the cells of origin, i.e. the glandular epithelium of the large bowel, express standard form of CD44 (CD44s), but not variant ones (CD44v), while highly dysplastic colorectal adenomas, primary and metastatic colorectal cancers express a large variety of different-length CD44 isoforms, both on mRNA and protein levels [14,31,44,77-79]. Here, CD44 is linked to colorectal adenoma.