Although the complete CD44 isoform list was not achieved, we identified simplified colorectal adenocarcinoma specific CD44 alternative splice pattern (ASP) which was qualitatively stable across samples from different colorectal cancer cell lines in vitro, and subcutaneous, intrasplenic and orthotopic implanted primary colorectal tumours and their liver metastases/colonies. The gene discussed is CD44; the disease is colorectal neoplasm.