This research group also found that PLK1 function appeared to be essential for centrosome-mediated microtubule events and, consequently, for spindle assembly and siRNAs targeted against human PLK1 might be valuable tools as antiproliferative agents against a broad spectrum of neoplastic cells including NSCLC cell line (A549)[10]. This evidence concerns the gene PLK1 and non-small cell lung carcinoma.