TLR3 and Hepatitis: Finally, a recent study regarding TLR3 polymorphisms and their association with hepatitis B virus (HBV) infection[18] found that whereas genetic variance (rs1879026/GT) was more common in HBV carriers than in uninfected controls haplotype analysis revealed that specific haplotypes GCGA (rs1879026, rs5743313, rs5743314, and rs5743315) were significantly associated with HBV infection.