As the children with pandemic A/H1N1/2009 influenza who were hospitalised for pneumonia were similar to those with pandemic A/H1N1/2009 influenza who were discharged from the Emergency Room because their disease was milder, this finding suggests that the TLR3 rs5743315/AC polymorphism per se may play a role in conditioning the risk of pneumonia in children infected by pandemic A/H1N1 influenza virus. The gene discussed is TLR3; the disease is influenza.