MDM2 and chronic myelogenous leukemia, BCR-ABL1 positive: The kinetic curves of the gene expression levels (GEL) of p53, p21, c-myc,bcr/abl, mdm2, bcl2, bax, bcr , which participate in the regulation ofthe cell cycle [14, 24, 28, 45–48,52, 58, 59], apoptosis [3, 14,16–22, 28, 42, 47, 49,50, 56, 58, 60], proliferation and differentiation, were obtained bycultivation of Ph +  mononuclear cells consisting of 95% myeloid Ph+  cells; i.e., upon CML-affected myelopoiesis [1–3, 24,26–28, 42, 43, 46, 48, 51–54, 57–68].