Overexpression of the genes bcr > gapdh > bcr/abl  anddiminished expression of р53, bcl2, mdm, р21 < gapdh are observed in type 1 Ph + cells derived during the blastcrisis and the CML acceleration phase with the efficiency indices P/D ~ 5–20and a high CD34 +  cell content. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.