MDM2 and chronic myelogenous leukemia, BCR-ABL1 positive: In the Ph+cells with a high P/D efficiency index (5–20), overexpression of thegenes in the range ofbcr> gapdh>bcr/abl, as well as adecreased expression of thep53, bcl2, mdm2, p21<< gapdhgenes is observed for Ph+cells from the CML blast crisis andCML acceleration phase.