The protective effect ofEC-SOD was attributed to the protection of the NO vascular dilator, which diffusesfrom the endothelium to the guanylate cyclase of smooth muscle cells [30, 32,37], which was confirmed with dataobtained from a model of volume-dependent (high-volume) hypertension in mice (1kidney, 1 clip) [38]. Here, SOD1 is linked to hypertensive disorder.