Indeed, treatment of T. cruzi-infected mice with Met-Rantes, a CCL5-based CCR5 antagonist, reduced the intensity of the inflammatory heart infiltrate, with little effect on parasitism [52], suggesting that CCL5-induced migration of CCR5 inflammatory cells may play a direct role in the genesis of acute T. cruzi-induced myocarditis. This evidence concerns the gene CCL5 and myocarditis.