While it is not known at present if the increased expression of SREBP1 induced by chiglitazar in tissues other than adipose tissue is beneficial, reduced expression of SREBP1 in skeletal muscle as well as adipose tissue was observed in obese and T2DM patients [21, 40], indicating the impaired regulation of the gene in insulin-resistant states. Here, SREBF1 is linked to type 2 diabetes mellitus.