At this point, it is also crucial to state that testicular dysfunction was only restored when it was associated to IGF-I deficiency conditions, since IGF-I treatment of rats with testicular damage secondary to epinephrine intra-scrotal injections (but without liver cirrhosis or any other condition of IGF-I deficiency) was not able to adequately recover their morphology and function. This evidence concerns the gene IGF1 and cirrhosis of liver.