In cross-sectional studies, low circulating IGF-I levels were found to be associated with angiographically documented coronary artery disease[275] and may predict fatal ischemic heart disease[272], a significantly increased risk of ischemic stroke and congestive heart failure in elderly patients[276,277], as well as a worse prognosis of recovery after an acute myocardial infarction[278]. This evidence concerns the gene IGF1 and coronary artery disorder.