In 1966, Zvi Laron et al. described the first condition of IGF-I deficiency as a new type of dwarfism indistinguishable from genetic isolated GH deficiency, but with unexpected high serum GH levels[199,200] and inability to synthesize IGF-I and other related molecules, as IGFBP-3[34,35,201]. This evidence concerns the gene GH1 and hyperinsulinemic hypoglycemia, familial, 4.