In fact, IL6 together with TGFβ pathways, a dual biomarker for Treg/Th17-network imbalance, were implicated in the EDSS increase in both untreated, men and women groups of MS patients (Figures 3c and 3d: the vectors of TGFβ, IL6 and EDSS are positively related). Here, TGFB1 is linked to myeloid sarcoma.