In addition, in a patient with immunodeficiency the infiltration may be the result of an antigenic trigger like an insect bite, a drug, or a virus which causes cytokine production with an excess of IL-4 and IL-5 and an altered immune response with prominent infiltration of the septa and/or lobules of the subcutaneous fat with eosinophils leading to EP [1]. This evidence concerns the gene IL5 and immunodeficiency disease.