To evaluate the potential of AQP5 and AQP8 as novel prognostic markers of CRC, we employed RT-PCR and immunohistochemical methods to detect the expression of AQP5 and AQP8 in clinical samples of CRC and then analyzed the correlations of their expression with the clinicopathological features of CRC. This evidence concerns the gene AQP8 and colorectal carcinoma.