Statistical analysis showed that AQP5 expression was not significantly associated with the sex or age of the patients with CRC (P>0.05), but was closely associated with the differentiation, tumor-nodes-metastasis (TNM) metastasis stage and distant lymph node metastasis of colorectal carcinoma (P<0.05) (Table1). This evidence concerns the gene AQP5 and colorectal carcinoma.