AQP5 and colorectal carcinoma: Furthermore, we analyzed the correlations of AQP5 expression with the clinicopathological features of CRC and found that AQP5 expression was not significantly associated with the sex or age of patients with CRC (P>0.05), but was closely associated with the differentiation, TNM stage and distant lymph node metastasis of colorectal carcinoma (P<0.05).