Analogy of kinase recognition and substrate interaction is shown by considering another substrate of ck1α which is p53 tumour suppressor transactivation domain[16] whose crystal structure is known[21].The residues found to interact in ck1α with the substrate constraint residue are common in the viral protein HCV NS5A and human p53 tumour suppressor transactivation domain. The gene discussed is TP53; the disease is neoplasm.