Principal component 1 was the only component able to show differences between subjects with and those without metabolic syndrome (PC1: p<0.001), and this diagnosis was associated with higher values of variables intrinsically related to insulin resistance but also to a prolonged microvascular reactive hyperemia response, such as BMI, waist circumference, systolic BP, diastolic BP, insulin, TG, CRP and TRBCVmax). This evidence concerns the gene INS and metabolic syndrome.