The normal-like subtype is also included in the triple negative breast cancer group (TNBC) characterized by an aggressive clinical course, poor survival rate and, unlike the overexpressing hormone receptors or c-erbB-2-overexpressing tumors, is not amenable to hormone therapy or c-erbB-2-directed agents[44]. The gene discussed is NR4A1; the disease is triple-negative breast carcinoma.