NR4A1 and neoplasm: Comparison of sporadic tumours in both sexes shows; a steady linear increase in incidence in men with age in contrast to the bimodal distribution seen in FBC [2,3,18], an older median age of diagnosis in men [6,8,18], more advanced stage-related tumour characteristics (tumour size >2cm, positive axillary nodes) [2,18] but with more favourable histopathological characteristics (lower tumour grade) and biology (hormone receptor positive tumours) [2,18].