PDGFRα exon 12 SNP (rs1873778), present in homozygosis in all CRC cell lines and 100% of analyzed tumor samples, has been also described in other neoplasias although in a smaller proportion of patients, including KIT and FLT3 mutation-negative core binding factor (CBFL) acute myeloid leukemias (14% of 35 patients)[25], cervical adenosquamous carcinomas (30% of 30 patients)[26] and gliomas (7% of 86 patients)[27]. This evidence concerns the gene FLT3 and central nervous system cancer.