The present study evaluated the incidence of VEGFR2, PDGFRα and PDGFRβ TK domain genetic variants in different CRC cell lines (T84, LOVO, LS174T, HT29, LS180, SW48, SW480, COLO205) and in tumor samples of 92 patients diagnosed of colorectal adenocarcinoma. The gene discussed is KDR; the disease is colorectal adenocarcinoma.