The same accounts for sMICA, that is cleaved from membranous MICA and has been shown to impair NKG2D mediated tumor surveillance in epithelial tumors [40], as well as it has shown potential as a prognostic parameter in hematopoietic malignancies since increased levels of sMICA were found in leukemia patients [41]. The gene discussed is KLRK1; the disease is leukemia.