A recent report confirmed a reduced cholesterol level in neural stem (NS) cell lines developed from embryonic brains of wild-type and knock-in HD mice expressing full-length endogenous normal HTT (Hdh7/7Q) or muHTT (Hdh140/140Q) but not in NS cell lines derived from embryonic stem cells of heterozygous knock-in HD mice (Hdh140/7Q) 11. The gene discussed is HTT; the disease is Huntington disease.