In determining the systemic cytokine environment in the participants relative to CHI3L1, we showed that levels of the measured Th1 and Th2 cytokines were not associated with CHI3L1 levels, perhaps due to the cytokines acting locally at sites of infection [2], but there was an inverse association between CHI3L1 and levels of IL-10 and IL-17A. The gene discussed is IL10; the disease is infection.