MEG3 and hepatocellular carcinoma: If the HCC samples are sorted according to their methylation status (i.e., hypomethylated, hypermethylated, and normomethylated, for threshold definition see “Materials and Methods”) the negative correlation between the methylation at the DLK1/MEG3-DMRs and the expression of the MEG3 RNA becomes obvious (Figure 3 A), Fisher's exact test: p = 0.018).