For example, H. pylori infection of gastric mucosa was associated with enhanced urokinase expression [38] and disease progression toward a severe, pre-malignant gastritis that is indicative of poor patient prognosis [50], [51], while induction of urokinase expression in B. burgdorferi-BMEC co-cultures resulted in plasminogen-to-plasmin activation and enhanced pathogen invasion of an in vitro BBB model [26]. The gene discussed is PLG; the disease is gastritis.