SOD2 and Cognitive impairment: Given the importance of mitochondria in neuronal functions and synaptic plasticities and the importance of MnSOD in the maintenance of mitochondrial functions and structural integrity, understanding how alterations in MnSOD affect hippocampal neurogenesis and dendritic maintenance, especially in the post-irradiation period, should provide a handle on how to manage the late effects of cranial irradiation and minimize the associated cognitive deficits.