Similar results were obtained when MS-275 and S-TRAIL combination was tested in culture on another TRAIL-resistant (UW473) medulloblastoma line engineered to express mCherry-Fluc (Fig. S4) Additionally, when MS-275 and S-TRAIL combination was tested on a TRAIL-sensitive (R262) medulloblastoma line engineered to express mCherry-Fluc, a significant decrease in cell viability was seen when cells were treated with MS-275 and co-cultured with hMSC-S-TRAIL as compared to each single treatment (Fig. S4). Here, TNFSF10 is linked to medulloblastoma.