In addition to its potential role in angiogenesis, BLT2-ROS signaling was recently shown to promote survival in estrogen receptor (ER)–negative, nonmetastatic breast cancer cells, such as MDA-MB-468 and MDA-MB-453 cells, although the downstream effectors of this BLT2-ROS pathway were not determined [13]. This evidence concerns the gene ESR1 and breast carcinoma.