As a pivotal component of multiple pathways, Akt has been shown to be a positive regulator of survivin expression in endothelial cells, and previous studies have claimed that the PI3K/Akt/survivin signaling pathway is an anti-apoptotic pathway in prostate cancer, lung cancer, myeloma, and leukemia [72], [73]. The gene discussed is BIRC5; the disease is plasma cell myeloma.