However, carcinoma samples with MMP-11 positive MICs showed a more important increase in the mRNA level of 19 factors: IL-1, −5, −6, −8, −17 and −18, ADAM-8, −10, −15, and −23, ADAMTS-1, −2, and −15, IFNβ, MMP-1, as well as mediators related to inflammation (CCL-3, IRAK-4, MyD88 and NFκB). The gene discussed is IRAK4; the disease is carcinoma.