Sustained activation of the Wnt/ß-catenin pathway induced by gain-of-function mutations of activators of the Wnt pathway, for e.g. mutations in the ß-catenin gene that enhance its stability, or mutations in genes that control ß-catenin stability like APC, the Axins, or E-cadherin, is found in various cancers [3], [4]. This evidence concerns the gene CDH1 and cancer.