While Pgc-1α induced DA depletion is an important concern for the use of full-length Pgc-1α gene therapy as a neuroprotective in PD, it is unlikely to have direct ramifications for Pgc-1α overexpression strategies in other areas of the brain since the expression of Pitx3 is localized to midbrain neurons. The gene discussed is PITX3; the disease is Parkinson disease.