The results showed that in BGC-823 cells with knock-down of IQGAP1 expression, infection with adenovirus encoding constitutively active RhoC could not stimulate the proliferation activity anymore; while in BGC-823 cells with knock-down of RhoC expression, over-expression IQGAP1 or IQGAP1-C through infecting the cells with adenovirus encoding the corresponding DNA still caused higher proliferation activity. The gene discussed is RHOC; the disease is infection.