Increased SCD activity is indicated by the orange arrows between all SCD-linked SFAs and MUFAs (e.g. 16∶0 to 16∶1n7 and 18∶0 to 18∶1n9 nodes), while the diabetes-associated decrease in SPCS activity is reflected in the blue arrows linking 22∶6n3 with 22∶5n3 and 22∶4n6 with 22∶5n6. Here, SCD is linked to diabetes mellitus.