The TMPRSS6 p.736Val allele was negatively associated with hepatic iron accumulation independently of age, gender, the presence of HFE genotypes at risk, and the beta-thalassemia trait (OR 0.59, 95% confidence interval 0.39–0.88, per each p.736Val allele). The gene discussed is TMPRSS6; the disease is Beta-thalassemia.