Among them, the knockout line reported by Harroch et al. exhibits a fragility of myelin in the CNS [19] and impaired remyelination after experimental autoimmune encephalomyelitis (EAE)-induced demyelination [20], suggesting conversely a positive role for Ptprz in oligodendrocyte survival and in recovery from demyelinating disease. Here, PTPRZ1 is linked to experimental autoimmune encephalomyelitis.