In this study, we used the standard murine model of disseminated candidiasis because of its similarities to severe human systemic infection [20] and demonstrate that endogenous TSP1 enhances the susceptibility of mice to disseminated C. albicans infection by potentiating the early renal host inflammatory response and inhibiting phagocytic clearance of C. albicans (Figure 7). The gene discussed is THBS1; the disease is disseminated candidiasis.