We next examined the effect of tankyrase inhibitors in two other breast cancer cell lines, MCF-7 cells which are human epithelial-like cells of the Luminal A subtype that lack autocrine Wnt but are responsive to exogenous ligand [41], [44], [47] and EMT6 cells, a sarcoma-like mouse mammary breast cancer cell line, that has been utilized widely as a model system to study the effects of various treatments on local tumor growth and pulmonary metastasis [48], [49], [50]. The gene discussed is TNKS; the disease is breast cancer.