The effect size of this SNP is comparable to the effect sizes for ADRs in other reports where the OR ranges from 2.2 (HLA-A*020 allele in drug induced liver injury) [32] to 9 (rs1805128 allele in KCNE1 for drug-induced Torsades de Pointes) [33] and >20 (HLA-A*3101 allele in Stevens–Johnson syndrome and toxic epidermal necrolysis) [34]. Here, HLA-A is linked to toxic epidermal necrolysis.