In this context, some tumour cells adopt an amoeboid form of movement [15], [16] that is characterized by a rounded, blebbing cell morphology, independence from extracellular proteases and the requirement of high levels of Actomyosin contractility downstream of the RhoA-ROCK pathway to deform the extracellular matrix and drive cell movement [17], [18], [19], [20]. The gene discussed is RHOA; the disease is neoplasm.