Two of these 16 genes, S100 calcium binding protein A16 (S100A16) and maternally expressed 3 (non-protein coding) (MEG3), were also gained and under-expressed in 7 and 6 of 29 osteosarcoma clinical samples, respectively, based on identical types of microarray data (no methylation data was available) [27]. This evidence concerns the gene S100A16 and osteosarcoma.