GPT and Hyponatremia: Specifically, LCM B subtypes with worse prognoses were associated with first with worsening LV and RV ejection fraction followed by evidence of worsening cardiac output (higher heart rate, lower systolic and pulse pressure, and hyponatremia) and finally worsening evidence of volume overload (increasing jugular venous distension, blood urea nitrogen, and alanine aminotransferase).